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awareness month

2017

Building Capacity and Sharing Success Stories in HIV-Associated Malignancy Research in Sub-Saharan Africa 

Day 1
Introduction and opening remarks

by Drs. Busakhala, Loehrer

Principles of Conducting Clinical Research

 

Principles of Conducting Population & Epidemiologic Research

 

Grant Writing: Constructing your Hypothesis and Aims

 

Training in Responsible Conduct  as a Researcher: NIH Guidelines

 

Breakout Session-1:

What are the key research issues in sub-Saharan Africa for HIV infected patients and  cancer? {Each Consortia should be prepared to contribute examples based on pre-meeting queries}

 

Breakout Session- 2:

What specific collaborative research proposals can address the issues defined above? {Each Consortia should be prepared to contribute examples based on pre-meeting queries}

 

Reports from Breakout sessions
Breakout Session- 3:

Mentoring (Senior, junior faculty and trainees): Discuss and develop proposals concepts

Day 2
Opening Remarks

by Dr. Orango Omenge

 Plenary Session: Integration of Primary Care and HIV-Associated Malignancies: The AMPATH Model-by Rachel Vreeman or Bob Einterz
 

Developing Workforce Capacity in LMIC

Professional Development and Training (Chairs: Uganda/Hutch & IUSCC/AMPATH Consortia Leaders)
Training and Other Grant Opportunities (NIH)- five minute presentations each

·    D43-  (TBD)

·    Fogarty- (TBD)

·    ASCO- (TBD)

·   Upcoming conferences and Tips for Abstract               submissions (TBD)

 U-54 Pilot Project highlights

·   All eight consortia present

.   5 slides in five minutes

.   Process of Selections (list project)

.  Highlight of one key example (also refer to the Posters)

KS/KSHV Related Consortia Projects (Presented by African Colleagues)
Kaposi Sarcoma early diagnosis (Uganda-IDI)
Characterization of the KSHV nAb response and its association with KSHV viral load and HIV-1 or KS treatment (Tanzania)
KS in spite of cART (Uganda-IDI)
HHV-8 Genomic Variability and the Natural History of KS (Uganda-UCI)
HPV/Cervical Cancer Related Consortia Projects (Presented by African Colleagues)
HPV and Cervical Cancer Screening (Rwanda)
HPV Diversity and Disease Outcomes of Cervical Cancer (Uganda-UCI)
Prevention and Early Detection of Cervical Cancer Through Self-Administered Screening in the Community (Uganda-IDI)
Factors Associated with HPV Screening and Acquisition in Young Women in Botswana (Botswana)
Modifiable factors predicting persistence of oncogenic HPV and cervical dysplasia in HIV+ Kenyan Women (Kenya)
Impact of immune reconstitution on outcomes to chemoradiation in cervical cancer (Botswana)
Day 3
Opening Remarks

Dr. Darron Brown

Trending Science Topics
Infection Associated Cancers and HIV: Dangerous Liaisons

by Charles Wood

Cancer Treatment for HIV-positive patient in Sub-Saharan Africa:

Where are we? (TBD)

Diagnosing and Treating Lymphoproliferative Disorders in Africa (Satish Gopal)
IeDEA as a Platform for Cancer Surveillance

by Jeff Martin

Panel Discussion: Opportunities for Collaborations in Clinical and Population Research
U54 Consortia Meeting-Lessons Learned
Panel 1 (Uganda and Kenya)

·        Kenya-AMPATH-U. Indiana

·        Uganda-UCI-Fred Hutch

·        Uganda-IDI-UCSF

·        Uganda-Mulago-Johns Hopkins

Panel 2 (Botswana, Malawi, Rwanda and Tanzania)

·        Botswana-UPENN

·        Malawi-Lighthouse-UNC

·        Rwanda-Rwanda Military-Einstein

·        Tanzania-ORCI-U. Nebraska

Conducting Genomic Research in LMIC: Ethics and feasibility
Pathology capacity Building and Tumor registries in LMIC
Developing Informatics in resource poor settings
New Technologies research and development for LMIC
Discussion on the following questions:

·        What are the impactful collaborative research questions for

Sub-Saharan Africa?

·        What should the future Direction of U54 Consortium Partners

be?

·        Other Questions

Summary and Conference Closing

2018

U54 Consortia Conference HIV Associated Malignancies in Low- and Middle-Income Countries

Day 1
Welcome from Malawi

by Sam Phiri (Lighthouse), Satish Gopal (UNC)

Welcome from NCI

by  Geraldina Dominguez (NCI), Johnan Kaleeba (NCI)

Opening remarks from Guest of Honor, Malawi Principal Secretary for Health

Dan Namarika (MOH)

Introduction of Argentina-Miami consortium

by Omar Coso, Ezequiel Lacunza, Diego Croci

Introduction of Nigeria-Northwestern consortium

by Lifang Hou, Rob Murphy, Sade Ogunsola, Solomon Sagay, Johan Musa, Emuobar Odeghe

 Introduction of Zambia-Nebraska consortium

by Charlie Wood, Chipepo Kankasa, Owen Ngalamika, Peter Julius

Fogarty K43 and other relevant opportunities

by Geetha Bansal (FIC)

 Non-NIH cancer career development awards open to international investigators

by Satish Gopal (UNC)

Perspectives from the Fogarty scientific review group Rob Murphy (Northwestern)
 NIH Center for Scientific Review ‘Tips for Applicants’ and ‘Peer Review Revealed’ videos
Discussion and questions from LMIC junior investigators posed to NIH sponsors and US senior investigators All
Scientific session: lymphoma, liver cancer, cancer epidemiology

Framing the discussion: what are key questions for lymphoma and liver cancer in LMIC?

by Satish Gopal (UNC), Greg Kirk (Hopkins)

HIV infection is associated with reduced survival among hepatocellular carcinoma cases from an urban referral hospital in Kampala, Uganda

by Sara Nsibirwa (Uganda-Hopkins)

Hepatic fibrosis in HIV-infected individuals in Uganda

by Clara Wekesa (Uganda-Hopkins)

Survival after HIV-associated cancer diagnosis in Malawi: results from a probabilistic linkage study

by Steady Chasimpha (Malawi-UNC)

Methodologic issues arising during probabilistic HIV-cancer data linkages in Malawi

by Marie-Josèphe Horner (Malawi-UNC)

DLBCL outcomes in Malawi: effect of HIV and derivation of a simplified prognostic score

by Matt Painschab (Malawi-UNC)

The impact of antiretroviral therapy on T-cell repertoire and immunologic characteristics associated with survival after a diagnosis of non-Hodgkin lymphoma in Uganda

by Abrahams Omoding (Uganda-Fred Hutch)

Wrap up questions and discussion All

 

Day 2

Scientific session: cervical cancer, anal cancer
Welcome and logistics

by Satish Gopal (UNC)

Framing the discussion: what are key questions for  cervical cancer in LMICs?

by Darron Brown (IU)

 Predictors of cervical cancer screening among women aged 25-49 in Botswana: a pilot study

by Bramwell Koyabe (Botswana-Penn)

Knowledge of cervical cancer and acceptability of prevention strategies among HPV-vaccinated and non-vaccinated adolescents in Eldoret, Kenya

by Anisa Mburu (Kenya-IU)

Uptake of a community-based screen-and-treat cervical cancer prevention strategy in rural Malawi

by Lameck Chinula (Malawi-UNC)

Loss to follow-up in a cervical cancer screening and treatment program in Western Kenya

by Stephen Kiptoo (Kenya-IU)

The impact of VIA screening and treatment with cryotherapy or LEEP in patients with HIV-infected and HIV-uninfected patients with cervical intraepithelial neoplasia

by Omenge Orang’o (Kenya-IU)

Clinical predictors of CIN2/3 in HIV-infected women undergoing treatment in Botswana

by Doreen Ramogola-Masire (Botswana-Penn)

Modifiable factors predicting persistence of oncogenic HPV and cervical dysplasia in HIV-infected and HIV-uninfected Kenyan women

by Philip Tonui (Kenya-IU)

Wrap-up questions and discussion All

 

Scientific session: cervical cancer, anal cancer 
Reconvening

by Satish Gopal (UNC)

Performance of Sacace™ HPV Genotypes 14 Real-TM Quant and careHPV™ against Linear Array® in Human Papillomavirus genotype detection during cervical cancer screening in women from Western Kenya

by Titus Maina (Kenya-IU)

Distribution of HPV subtypes associated with invasive cervical cancer in HIV-infected and HIV-uninfected women from Botswana

by Leabaneng Tawe (Botswana-Penn)

 HPV types and lineages in Uganda cervical carcinoma patients

by Noleb Mugisha (Uganda-Fred Hutch)

Prevalence of high risk HPV infection and E6/E7 oncoproteins among Rwandan HIV-infected women screened for cervical cancer

by Gad Murenzi (Rwanda-Einstein)

Cervical cancer screening in urban and rural areas of Tanzania reveals insights on the impact of HIV and multi-genotype HPV infections on cytological abnormalities

by Crispin Kahesa (Tanzania-Nebraska)

Public health approach to early detection of cervical cancer in Africa through community-based self-administered screening and mobile treatment provision

by Miriam Nakalembe (Uganda-UCSF)

Characterization of the tumour microenvironment in HIV-infected and unifected cervical cancer patients in Botswana

by Keabetswe Rahube (Botswana-Penn)

Anal and penile HPV among MSM in Rwanda

by Jean Sinayobye (Rwanda-Einstein)

Presentation of Botswana-Kenya inter-U54 pilot project

by Nicola Zetola (Penn)

Presentation of Kenya-Rwanda inter-U54 pilot project

by Omenge Orang’o (Kenya-IU)

Wrap-up questions and discussion All
Day 3
Welcome and logistics Satish Gopal (UNC)
Framing the discussion: what are key questions for Kaposi sarcoma in LMICs?

by Tom Uldrick (Fred Hutch)

Developing media to promote community awareness of early detection of Kaposi’s sarcoma in Africa
by Miriam Laker (Uganda-UCSF)
Rapid case ascertainment for Kaposi’s sarcoma: feasibility and field updates

by Aggrey Semeere (Uganda-UCSF)

Kaposi sarcoma in Malawi: early results from a prospective cohort

byJoe Gumulira (Malawi-UNC)

A newly established prospective cohort in the ART era of community-based newly diagnosed HIV-related Kaposi sarcoma in Africa
by Helen Byakwaga (Uganda-UCSF)
Comparative immunological profiling of African epidemic and endemic Kaposi Sarcoma patients in Tanzania
by Julius Mwaiselage (Tanzania-Nebraska)
Evaluating human herpesvirus-8 genomic diversity in Uganda

by Fred Okuku (Uganda-Fred Hutch)

KSHV-associated lymphoproliferative diseases in adults at a tertiary hospital in Malawi
by Tamiwe Tomoka (Malawi-UNC)
Presentation of Tanzania-Uganda inter-U54 pilot project

byWarren Phipps (Fred Hutch)

Wrap-up questions and discussion All
Open discussion:

• How can we facilitate inter-U54 collaboration?

• How can we facilitate interaction between the U54 network and other regional initiatives?

• What should competitive renewal of current 1st cohort of U54 consortia look like?
by Geraldina Dominguez (NCI), Johnan Kaleeba (NCI) and All

Meeting conclusion Sam Phiri (Lighthouse),

by Satish Gopal (UNC)

 

 

2019

Opening and HPV associated malignancies

Day 1
Welcome & opening remarks

by Hon. Dr Faustine Ndugulile, Deputy Minister for Health, Community Development, Gender,Elderly, and Children Faustine Ndugulile (MOH)
/Julius Mwaiselage (ORCI)/Robert Wilhelm & CharlesWood (UNL)

Overview of the NCI U54 program and its impact in developing countries

by Geraldina Dominguez

State of the art talk on HPV and associated cancers

by Joel Palefsky

U54 consortia cervical cancer & HPV-associated cancers projects presented by junior Investigators
A novel cervical cancer screen-and-treat demonstration project with HPV self-testing and thermocoagulation for HIV-positive women in Malawi

by Lameck Chinula (UNC Malawi)

HPV Types and Lineages in Uganda Cervical Carcinoma Patients

by Noleb Mugisha (UCI-FredHutch)

Cervical Cancer Screening in Urban and Rural Areas of Tanzania Reveals Insights on the impact of HIV and multi-Genotype HPV Infections on Cytological Abnormalities

by Kandali Samwel Kapie(ORCI-UNL)

Relative clinical performance of cervical cancer screening and triage tests in Rwandan women living with HIV

by Gad Murenzi (Rwanda-Einstein)

Predictors of uptake of cervical cancer screening among women living with HIV in the city of Kigali

by Lydia Businge (Rwanda-Einstein)

HIV status, age at initiation of screening for cervical cancer and cytology outcomes in an opportunistic screening setting in Jos Nigeria: a 10-year cross-sectional data analysis

by Jonah Musa (U Jos-Northwestern)

Evaluation of a public health-based village health team-delivered campaign to mobilize women for community-based self-administered cervical cancer screening

by Miriam Nakalembe (Uganda-UCSF)

Prevalence of genital human papillomavirus infection among healthy young women inBotswana

by Kebatshabile Ngoni (Botswana-UPenn)

Prenatal cervical cancer screening using visual inspection with acetic acid in a low resource setting

by Vincent Oyiengo (Kenya-Indiana)

An exploration into the quality of life of women treated for cervical cancer at a teaching hospital in western Kenya

by Caroline Sabulei (Kenya-Indiana)

Histopathology profile of ocular surface tumors in an era of anti-retroviral therapy at the University Teaching Hospital, Lusaka, Zambia

by Peter Julius (Zambia-UNL)

Human papillomavirus and Kaposi sarcoma associated herpes virus infection among a men who have sex with men and transgender women from Argentina

by Valeria Fink (Argentina-Miami)

Anogenital human papillomavirus infection in HIV infected and HIV uninfected men who have sex with men in Rwanda

by Thierry Muvunyi Zawadi(Rwanda-Einstein)

 Detection of oncogenic human papillomavirus by HIV status in Kenyan women enrolled in a longitudinal study of factors predicting cervical dysplasiaby Philiph Tonui (Kenya-Indiana)

Detection of aflatoxin in plasma of Kenyan women is associated with increased detection of
oncogenic HPV

by Omenge Orang’o (Kenya-Indiana)

 

Day 2

U54 consortia Kaposi’s sarcoma and other KSHV

associated cancer projects presented

by Junior investigators

Evaluating HHV-8 Genomic Diversity in Kaposi Sarcoma in Uganda

by Fred Okuku (UCI-Fred Hutch)

Comparative Immunological Profiling of African Endemic and Epidemic Kaposi’s Sarcoma Patients Reveals the Primary Role of KSHV in KS Pathogenesis

by Salum Lidenge (ORCI-UNL)

Determinants of Survival among a Community-Based Sample of Patients with HIV-related Kaposi Sarcoma Identified by Rapid Case Ascertainment

by Helen Byakwaga(Uganda-UCSF)

Similar gene expression between endemic and epidemic KS patients irrespective of ART treatment status

by Owen Ngalamika (Zambia-UNL)

Chemotherapy use among HIV-infected patients in East Africa newly diagnosed with Kaposi’s Sarcoma who are identified by rapid case ascertainment

by Aggrey Semeere (Uganda-UCSF)

Oncogenomics and bioinformatics analysis of virally induced AIDS-associated cancers

by Martin Abba (Argentina-Miami)

Why are they diagnosed so late? Understanding the circumstances preceding diagnosis amongst patients with Kaposi sarcoma identified by rapid case ascertainment

by Miriam Laker-Oketta (Uganda-UCSF)

Presentations of the two ongoing inter-U54 pilot projects (Kenya-Rwanda / Tanzania-Uganda)

by Omenge Orang’o / John Ngowi Richard & Fred Okuku

Point of care KS diagnostics Jeff Martin (UCSF)
U54 consortia lymphoma, liver, & other cancer projects presented by junior investigators
Burkitt and plasmablastic lymphoma in Malawi

by Takondwa Zuze (UNC-Malawi)

The impact of antiretroviral therapy on T-cell repertoire and immunologic characteristics associated with survival after a diagnosis of non-Hodgkin lymphoma in Uganda

by Abrahams Omoding (UCI-Fred Hutch)

Evaluation of REDCap as a Data Collection and Quality Improvement Tool for Cutaneous Lymphomas in Botswana

by Kagiso Ndlovu (Botswana-UPenn)

Severe liver disease among HIV-infected patients attending care clinics in Uganda

by Clara Wekesa (JHU-Uganda)

A hepatitis B education intervention for pregnant women attending routine antenatal clinics in Uganda

by Joan Mutyoba (JHU-Uganda)

Characteristics of Hepatitis B virus and Hepatitis C virus associated hepatocellular carcinoma in Nigerians

by Emuobor Odeghe (Lagos-Northwestern)

Final remarks and summary
Day 3

Overview of NIH funded programs in sub-Saharan Africa

by Geetha Bansal

Strategies of new and established consortia to sustain beyond the U54 (moderated panel discussion)

by Julius Mwaiselage(ORCI), Jeff Martin(UCSF), OmengeOrang’o (Moi)

How can research be meaningfully prioritized by Ministries of Health and be sustained in sub-Saharan Africa?

by Ministry of Health (TBD)

How can we further facilitate meaningful inter-U54 scientific collaboration? (moderated panel discussion)

by Warren Phipps, John West, Pat Loehrer

NCI perspective/plans for continued support/renewal of the U54 consortia, and open discussion on the future of the U54 consortia network

by Geraldina Dominguez, Johnan Kaleeba (NCI)

Review of grant opportunities available to international investigators

by Tisha Mullen, Matthew Dwyer

Understanding the various grant components

Understanding the grant review process
Success stories of African earlier career investigators

by Nixon Niyonzima (UCI-FredHutch),Owen Ngalamika (UTH-UNL), Lameck Chinula (UNCMalawi)

Writing specific aims
Writing the research strategy
Writing individual’s specific aim
Specific aims display, viewing and networking

Formation of inter-U54 pilot project proposal teams