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Background

The primary issues...

Cervical cancer continues to be a major worldwide health concern and makes up about 12% of all the cancers in women. It is one of the major AIDS defining cancers in HIV positive women with an impact which is felt generally across the low and middle income countries…
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Mission

What we're doing in Botswana

To build research capacity and infrastructure together with developing culturally appropriate and sustainable cervical cancer interventions at the University of Botswana.

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Aim

How we intend to reach our goals

To develop a creative comprehensive and interdisciplinary cervical cancer research program on women to address the urgent need to lower the burden and associated morbidity and mortality of HIV-associated cervical cancer…
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Vision

At the core of our beliefs

To be a provider of solutions that are innovative and cost effective in the curing and prevention of cervical cancer in Botswana.

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Background

Status Quo

Cervical cancer continues to be a major worldwide health concern and makes up about 12% of all the cancers in women. It is one of the major AIDS defining cancers in HIV positive women with an impact which is felt generally across the low and middle income countries……Read More…

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Aims

and Methodologies

To develop a creative comprehensive and interdisciplinary cervical cancer research program on women to address the urgent need to lower the burden and associated morbidity and mortality of HIV-associated cervical cancer….
Read More…

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Mission

Statement

To build research capacity and infrastructure together with developing culturally appropriate and sustainable cervical cancer interventions at the University of Botswana…

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Competitive pricing

Get the best quality for lowest rates

To be a provider of solutions that are innovative and cost effective in the curing and prevention of cervical cancer in Botswana..

Meet Our Team

Highly qualified professionals

Project 1

Natural history and pathogenesis of HPV in HIV Infected women with cervical cancer

Project 2

Factors associated with HPV screening and acquisition in young women in Botswana

Project 3

“The impact of HIV infection and immune reconstitution on tolerability and response to chemo-radiation for cervical cancer”

Administrative Core (Core A)

Shared Resources Core (Core B)

Biostatistics and Data Management Core (Core C)

Mentoring and Career Development Core (Core D)

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Erle Robertson : Project I Principal Investigator

Erle

John Jemmott : Project II Principal Investigator

John B. Jemmott III

Surbhi Grover : Project III Principal Investigator

Surbhi Grover

Erle Robertson : Leader of Core A

Erle

Nicola Zetola : Leader of Core B

Nicola Zetola

Rosemarie Mick : Leader Core C

Rosemarie Mick

Harvey Friedman : Leader Core D

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Doreen Ramogola-Masire : Project I In-country Principal Investigator

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Bagele Chilisa : Project II In-country Principal Investigator

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Memory Bvochora : Project III In-Country Principal Investigator

Memory

Bagele Chilisa : Co Leader Core A

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Surbhi Grover : Co Leader Core B

Surbhi Grover

Lesego Gabaitiri : Co Leader Core C

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Oathokwa Nkomazana : Co Leader Core D

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Our Projects

There are three proposed research projects that address women in different settings. These are

Project 1

Natural history and pathogenesis of HPV in HIV Infected women with cervical cancer

This project will explore the interaction of HIV and its associated immunosuppression with HPV (and other infections including other sexually transmitted infections [STI]) infection and how this interaction leads to the development of cervical cancer.

Project 2

Factors associated with HPV screening and acquisition in young women in Botswana

This project will explore the behavioural aspects that lead to 1) the acquisition of HIV, HPV, and STI; 2) the decisions to engage in cervical cancer screening, and 3) the decisions to seek and continue therapy for cervical cancer.

Project 3

“The impact of HIV infection and immune reconstitution on tolerability and response to chemo-radiation for cervical cancer”

This project will explore the role of immunosuppression and response to treatment (chemoradio-therapy) once cervical cancer develops for developing effective treatment regimens.

Methodologies

Three cohorts of women in Botswana who form the basis of the program will be recruited as follows

Cohort 1

Young women who are first years at UB who have varying risks of acquiring HIV, HPV and STI.

The aim is to identify the microbial signature patterns in cervical carcinoma which may provide insights as to the contributions of these agents to the initiation and development of cervical cancers.

Cohort 2

HIV-infected women with cervical intraepithelial neoplasia (CIN) lesions found on routine screening.

The aim is to identify the factors that determine progression of early HPV cervical lesions to more advanced lesions in HIV-infected women.

Cohort 3

Women with cervical cancer receiving treatment.

The aim is to improve survival in HIV+ women undergoing chemo-radiotherapy by defining the clinical (tolerability and toxicity) and immunological parameters associated with invasive cervical cancer therapy response.

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Research Program

The capacity and infrastructure building will be organized around four cores.

  • Administrative Core (Core A)
  • Shared Resources Core (Core B)
  • Biostatistics & Data Management Core (Core C)
  • Mentoring/Career Development Core (Core D)
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